The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemicReview Published on 2022-12-012023-07-10 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] Apoptosis Caspases Cathepsins cell death COVID-19 Lysosomes Proteases pyroptosis SARS-CoV-2. [DOI] 10.1007/s43440-022-00394-9 PMC 바로가기 [Article Type] Review
A Shift in SARS-CoV-2 Omicron Variant’s Entry Pathway Might Explain Different Clinical OutcomesArticle Published on 2022-10-312023-07-10 Journal: MEDICC review [Category] COVID19(2023년), [키워드] Ageusia Anosmia brain stem Cathepsins COVID-19 COVID-19 pandemics Endosomes olfactory nerve Respiratory Center SARS-CoV-2 Smell Taste. [DOI] 10.37757/mr2022.v24.n3-4.10 PMC 바로가기
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into CellsSARS-CoV-2 세포로의 진입을 완전히 차단하려면 Vacuolar-ATPase 및 TMPRSS2의 이중 억제가 필요합니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ATPase bafilomycin block viral entry camostat cathepsin inhibitor Cathepsins Cell cellular Compound coronavirus E64d Efficacy endosomal pH endosomal protease endosome expressing highlight host cell host protease host proteases Hydroxychloroquine identify implicated Infection inhibit inhibiting inhibition inhibitor inhibitors Intervention life cycle Macrolide maturation mechanisms membrane fusion molecules Neutralizing nonspecific Pathways pharmacological agent Prevent protease Protein proteolytic activation provide pseudotyped rationale S protein SARS SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine serine 2 serine proteases severe acute respiratory syndrome Coronavirus synergy the S protein these compound these compounds TMPRSS2 TMPRSS2 inhibitor TMPRSS2-expressing cells toxicities Toxicity transmembrane V-ATPase viral entry viral spike virus virus. [DOI] 10.1128/aac.00439-22 PMC 바로가기 [Article Type] Article
Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases사용 가능한 세포 프로테아제에 대한 신속한 SARS-CoV-2 적응Article Published on 2022-03-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 binding cathepsin Cathepsins cleavage clinical isolates conditions Consensus coronavirus coronavirus spike priming deep sequencing delta variant dominant Efficiency Evolution furin furin cleavage motif furin cleavage site Genome genomes genomic Genotype growth heparan sulfate highlight human cell human cells identify independent inhibit isolate isolates lack mechanism minor motif mutated Omicron variant processed protease Proteases Rapid recent S1/S2 site SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure selective sequence spike mutation spike mutation. Spike protein spike protein of SARS-CoV-2 spike variant stability subpopulation sulfate Surveillance the spike protein These cells TMPRSS2 variant variants Vero Vero E6 Vero E6 cell VERO E6 cells virus virus growth virus pathogenesis wild type [DOI] 10.1128/jvi.02186-21 PMC 바로가기 [Article Type] Article
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L천연물 갈린아미드 A 및 카텝신 L의 억제를 통한 유사체에 의한 강력한 항-SARS-CoV-2 활성Article Published on 2022-02-242022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activity analogue analogues Antiviral antiviral activity cathepsin cathepsin L Cathepsins Cell cell entry coronavirus COVID-19 cysteine cysteine protease drug target Efficacy highlight Host host protease in viral in vitro inhibit inhibited inhibition inhibitor involved natural overexpressing potent product protease SARS-CoV-2 SARS-COV-2 infection selectivity Serine serine 2 synergistic These data TMPRSS2 TMPRSS2 inhibitor transmembrane viral entry [DOI] 10.1021/acs.jmedchem.1c01494 PMC 바로가기 [Article Type] Article
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations노화된 전혈 전사체는 SARS-CoV-2 관련 혈관 및 면역 변화에 대한 후보 유전자를 나타냅니다Article Published on 2022-02-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adhesion affected age aging alteration anti-apoptotic BAG3 Blood Blood clots blood component blood components candidate candidate gene cascade cathepsin Cathepsins CCL4L2 CD14 CD4 CD8 Cell changes in clinical manifestation coronavirus COVID-19 CTSE CTSW database DEGs differentially expressed gene Differentially expressed genes DUSP4 expressed expression expression levels expression profile FASL FASLG female genders gene expression profile high viral load highest HLA-DRA Hyperinflammatory identify IFN IFN signaling immune immune response increase increase in increased expression individual Inflammation interact Interaction interferon investigated involved LAG3 Monocytes naïve T cells natural killer cell Natural killer cells Older older patient older patients overexpress overexpression PDCD1 Peripheral blood Platelet prediction Protein reveal RGS2 risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients sequencing data severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling Single-cell RNA-sequencing T cell T cell exhaustion T cells T lymphocytes target targets therapeutic TIGIT TOX Transcriptome translated type I interferon Vascular VCAM1 Viral load Viral protein Viral proteins Whole blood whole blood transcriptome whole blood. [DOI] 10.1007/s00109-021-02161-4 PMC 바로가기 [Article Type] Article
Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestationsResearch article Published on 2021-09-292022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] age analysis binding binding ability Brain cathepsin Cathepsins Complexes COVID-19 COVID-19 infection CTSL cyclosporine disorder disorders drug Drug repurposing expression Health host cells Hypothesis identify involved lysosomal cathepsins mitigate molecular molecular docking Neurological disorders neurological manifestation neurological manifestations performed potential therapeutic target Proteases required SARS-CoV-2 SARS-CoV-2 entry shown stability targeting virus entry [DOI] 10.1016/j.heliyon.2021.e08089 [Article Type] Research article
Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism환경으로 유발 된 MDIG는 SARS-COV-2 수용체 NRP 및 글리 칸 대사의 발현을 육성함으로써 COVID-19의 심각성에 기여한다.Research Paper Published on 2021-07-062022-09-10 Journal: Theranostics [Category] SARS, 변종, [키워드] mdig Air pollution arsenic bronchial epithelial cell bronchial epithelial cells Cathepsins causative agent ChIP-seq contribute coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR cytokine Cytokine storm death decreased expression Depletion determinant determined by Effective strategies effective strategy elevated ENhance environmental exposure environmental factor environmental factors Epidemiological study epithelial cells Evidence expression expression of SARS-CoV-2 Genetic glycosylation induce Inflammation involved lysine mediator metabolism Mortality Neanderthal neuropilin Neuropilin-1 NRP1 NRP2 oncogene patients Protein Proteins provided recent receptor reducing reported SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 receptors severity of COVID-19 suggested Symptom These data variant Viral viral infection β-coronavirus [DOI] 10.7150/thno.62138 PMC 바로가기 [Article Type] Research Paper
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapySARS-CoV-2와 숙주 세포 간의 상호 작용의 분자 메커니즘 및 중재 요법Review Published on 2021-06-112022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 신약개발, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-SARS-CoV-2 Activity antibodies antiviral therapy Cathepsins caused clinical trial clinical trials Complexes Compound conformational coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 curtail drug explain furin fusion peptide Health help host cell host cells Infection Infectious diseases information Interaction knowledge mechanism membrane fusion molecular mechanism neuropilin Neuropilin-1 pandemic peptide peptides postfusion prefusion Prevention and control protease Proteases Protein receptors reduce respiratory responsible SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus suppress therapy tissue tropism TMPRSS2 Transmissibility Vaccine variety Viral virulence [DOI] 10.1038/s41392-021-00653-w PMC 바로가기 [Article Type] Review